【关键词】Heavy metals ,Renal function ,8-OHG ,Exposure-response relationship ,Mediation analysis
【DOI】https://doi.org/10.1016/j.envpol.2022.120727
【影响因子(IF)】9.98
【出版期刊】《Environmental Pollution》
【产品原文引用】
The following biomarkers for renal function were measured in urine: creatinine (Cr), β2-MG, NAG, RBP and 8-OHG. The concentration of Cr and NAG were measured by a creatinine assay kit (Nanjing Jiancheng Bioengineering Institute, China) and NAG kit (Nanjing Jiancheng Bioengineering Institute, China), respectively. β2-MG, RBP and 8-OHG were determined by the QuicKey Human BMG/β2-MG (Beta-2-Microglobulin) ELISA Kit (Elabscience Biotechnology Co. Ltd, China), Human RBP ELISA KIT (Shanghai Hengyuan Biological Technology Co. Ltd, China) and Human 8-OHG ELISA KIT (Shanghai Hengyuan Biological Technology Co. Ltd, China), respectively, according to the instructions of the manufacturer. The assay range of β2-MG, RBP and 8-OHG were 0.78–50 μg/L, 2–65 μg/L and 3–100 ng/L, respectively. All operation steps were strictly carried out according to the instructions of the kit.